University Freiburg
Chair for Bioinformatics
Institute of Computer Science

Software/Server

Server and Web-Applications

INFO-RNA - A Server for Inverse Folding of RNA
SECISDesign - A Server to Design SECIS-Elements within the Coding Sequence
CPSP web tools     (Note: BETA version ... please report bugs!)
Includes: Optimal protein structure prediction in the HP-model, Viewing, Conversion between structure representations, ...
FCC-HP protein
MARNA - A Server for Multiple Alignment of RNAs Multiple Alignment of RNAs
TassDB - TAndem Splice Site DataBase
NIPU server - Display splicing regulatory motifs and single-stranded mRNA regions
BioBayesNet - a web server for feature extraction and bayesian network modeling of biological sequence data
LocARNA Server (@ TBI) - Multiple Alignment of RNAs

Software and Libraries

IntaRNA - 1.2.2 (2009-09-30) NEW Version - Efficient Target Prediction Incorporating Accessibility of Target Sites
Default parameters have changed with version 1.2.
To use IntaRNA, you need the library of the Vienna RNA Package (version ≥1.8.2). The latest version of the Vienna RNA Package version can be downloaded here.
If you use our tool for your own scientific publication, please cite our article.
Copyright by Anke Busch and Andreas S. Richter, 2008-2009.
LocARNA - Local Alignment of RNA.
A tool for pairwise and multiple, global and local alignment of RNA with simultaneous folding.
Copyright by Sebastian Will, 2006-2009.
ExpaRNA - 0.8 (2009-03-18) - formerly RNAexact)
C++ implementation to find the longest common subsequence of exact pattern matchings (LCS-EPM problem) of two RNAs given with their primary and secondary structure (mfe-structure is used if no structure is available).
Source is available as [tar.gz] or [zip]; compiles with Gnu C++ Compiler 4.x.
Copyright by Steffen Heyne, 2008-2009.
If you use ExpaRNA, please cite our article.

To use ExpaRNA, you need the library of the Vienna RNA Package that can be downloaded here.
ExpaRNA compiles also under cygwin for Windows!
usage example: ExpaRNA -L Examples/HCVirus_IRES_RNAs.fa
New in 0.8: Another nasty EPM bug is fixed, no open bugs anymore
New in 0.7.7: gaps are ignored in input sequences
New in 0.7.6: EPM bug-fix!!! start with new EPM scoring, see "-t" option
New in 0.7.1: EPM output (-e option), bug-fixes
New in 0.6: FASTA file input, LocARNA constrained output, removed XERCES-C dependency, code clean-up
INFO-RNA - A Fast Approch to Inverse RNA Folding Satisfying Sequence Constraints
INFO-RNA-2.1.tar.gz is available. Its a slightly modified version, which allows to design a random initializing sequence.
Older source is available as : INFO-RNA-2.0.tar.gz ( version 1.0 ).

To use INFO-RNA, you need the library of the Vienna RNA Package that can be downloaded here.
Copyright by Anke Busch, 2006-2007.
MEMERIS source code
CPSP-tools - Constraint-based Protein Structure Prediction tools CPSP-logo
ELL - Energy Landscape Library ELL-logo
BIU - Bioinformatic Utility Library BIU-logo
LatPack Tools and LatFit
C++ implementation of folding simulations approaches for arbitrary lattice protein models as well as fitting of 3D PDB structures onto lattices.
Copyright by Martin Mann, 2008.
side chain lattice protein fit
RNA Energy Landscape Tools barrier tree
Local Sequence Structure Aligment.
C++ implementation for our paper Local Sequence-Structure Motifs in RNA
Please cite this article, if you use the program for a publication.
Source is available as [tar.gz] or [zip]; compiles with Gnu C++ Compiler 3.x.
Copyright Sebastian Will .
CTE-Alignment - Efficient Sequence Alignment with Side Constraints by Cluster Tree Elimination.

Copyright by Sebastian Will.