@Article{Zhang_Pitchiaya_Cieslik-Analy_the_andro-2018,
  author =	 {Zhang, Yajia and Pitchiaya, Sethuramasundaram and Cieslik, 
                  Marcin and Niknafs, Yashar S. and Tien, Jean C-Y and Hosono, 
                  Yasuyuki and Iyer, Matthew K. and Yazdani, Sahr and 
                  Subramaniam, Shruthi and Shukla, Sudhanshu K. and Jiang, Xia 
                  and Wang, Lisha and Liu, Tzu-Ying and Uhl, Michael and 
                  Gawronski, Alexander R. and Qiao, Yuanyuan and Xiao, Lanbo 
                  and Dhanasekaran, Saravana M. and Juckette, Kristin M. and 
                  Kunju, Lakshmi P. and Cao, Xuhong and Patel, Utsav and 
                  Batish, Mona and Shukla, Girish C. and Paulsen, Michelle T. 
                  and Ljungman, Mats and Jiang, Hui and Mehra, Rohit and 
                  Backofen, Rolf and Sahinalp, Cenk S. and Freier, Susan M. 
                  and Watt, Andrew T. and Guo, Shuling and Wei, John T. and 
                  Feng, Felix Y. and Malik, Rohit and Chinnaiyan, Arul M.},
  title =	 {Analysis of the androgen receptor-regulated {lncRNA} 
                  landscape identifies a role for {ARLNC1} in prostate cancer 
                  progression},
  journal =	 {Nat Genet},
  year =	 {2018},
  volume =	 {50},
  number =	 {6},
  pages =	 {814-824},
  user =	 {backofen},
  pmid =	 {29808028},
  doi = 	 {10.1038/s41588-018-0120-1},
  issn = 	 {1061-4036},
  issn = 	 {1546-1718},
  abstract =	 {The androgen receptor (AR) plays a critical role in the 
                  development of the normal prostate as well as prostate 
                  cancer. Using an integrative transcriptomic analysis of 
                  prostate cancer cell lines and tissues, we identified ARLNC1 
                  (AR-regulated long noncoding RNA 1) as an important long 
                  noncoding RNA that is strongly associated with AR signaling 
                  in prostate cancer progression. Not only was ARLNC1 induced 
                  by the AR protein, but ARLNC1 stabilized the AR transcript 
                  via RNA-RNA interaction. ARLNC1 knockdown suppressed AR 
                  expression, global AR signaling and prostate cancer growth 
                  in vitro and in vivo. Taken together, these data support a 
                  role for ARLNC1 in maintaining a positive feedback loop that 
                  potentiates AR signaling during prostate cancer progression 
                  and identify ARLNC1 as a novel therapeutic target.}
}