@InProceedings{Will:Busch:Backofen:_effic_const_sequen_align_clust_tree_elimin:WCB05, author = {Sebastian Will and Anke Busch and Rolf Backofen}, title = {Efficient Constraint-based Sequence Alignment by Cluster Tree Elimination}, booktitle = {Proceedings of the Workshop on Constraint Based Methods in Bioinformatics (WCB05)}, year = 2005, pages = {66-74}, place = {Sitges, Spain}, user = {will}, publists = {All and Sebastian Will and Anke Busch and Rolf Backofen}, abstract = {Aligning DNA and protein sequences has become a standard mehtod in molecular biology. Often, it is desirable to include partial prior knowledge and conditions in an alignment. The most common and successful technique for efficient alignment algorithms is dynamic programming (DP). However, a weakness of DP is that one cannot include additional constraints without specifically tailoring a new DP algorithm. Here, we discuss a declarative approach that is based on constraint techniques and show how it can be extended by formulating additional knowledge as constraints. We take special care to obtain the efficiency of DP for sequence alignment. This is achieved by careful modeling and applying proper solving strategies.} }