@Article{Sonnleitner:Gonzalez:Sorger-Domenigg:The_small_RNA:2011,
  author =	 {Sonnleitner, Elisabeth and Gonzalez, Nicolas and 
                  Sorger-Domenigg, Theresa and Heeb, Stephan and Richter, 
                  Andreas S. and Backofen, Rolf and Williams, Paul and 
                  Huttenhofer, Alexander and Haas, Dieter and Blasi, Udo},
  title =	 {The small {RNA} {PhrS} stimulates synthesis of the 
                  {Pseudomonas} aeruginosa quinolone signal},
  journal =	 {Mol Microbiol},
  year =	 {2011},
  volume =	 {80},
  number =	 {4},
  pages =	 {868-85},
  user =	 {arichter},
  pmid =	 21375594,
  doi = 	 {10.1111/j.1365-2958.2011.07620.x},
  issn = 	 {1365-2958},
  issn = 	 {0950-382X},
  abstract =	 {Quorum sensing, a cell-to-cell communication system based 
                  on small signal molecules, is employed by the human pathogen 
                  Pseudomonas aeruginosa to regulate virulence and biofilm 
                  development. Moreover, regulation by small trans-encoded 
                  RNAs has become a focal issue in studies of virulence gene 
                  expression of bacterial pathogens. In this study, we have 
                  identified the small RNA PhrS as an activator of PqsR 
                  synthesis, one of the key quorum-sensing regulators in P. 
                  aeruginosa. Genetic studies revealed a novel mode of 
                  regulation by a sRNA, whereby PhrS uses a base-pairing 
                  mechanism to activate a short upstream open reading frame to 
                  which the pqsR gene is translationally coupled. Expression 
                  of phrS requires the oxygen-responsive regulator ANR. Thus, 
                  PhrS is the first bacterial sRNA that provides a regulatory 
                  link between oxygen availability and quorum sensing, which 
                  may impact on oxygen-limited growth in P. aeruginosa 
                  biofilms.}
}