@InProceedings{SiebertGCB03, author = {Sven Siebert and Rolf Backofen}, title = {{MARNA}: A Server for Multiple Alignment of {RNAs}}, booktitle = GCB, pages = {135-140}, abstract = {We describe an algorithmic method for multiple alignment of RNAs taking into consideration both the primary sequence and the secondary structure. In a first step, alignment edges between nucleotides are produced by pairwise sequence/structure comparisons of RNAs. They are weighted with similarity scores transformed from edit distances as proposed by Zhang. In a next step, the set of alignment edges are given as input to the multiple alignment program T-COFFEE. Here, edges that are supported by several pairwise alignments are strengthened. An example of tRNA sequences from the Rfam database with their typical cloverleaf structure is given. In addition, we compare this alignment with a traditional multiple sequence alignment program: clustalw. The MARNA server is available at http://www.bio.inf.uni-jena.de/Software/MARNA/marna.html}, year = 2003, month = {October}, user = {siebert} }