@InProceedings{Schmiedl:etal:_exparnap:RECOMB2012, author = {Christina Schmiedl and Mathias M{\"o}hl and Steffen Heyne and Mika Amit and Gad M. Landau and Sebastian Will and Rolf Backofen}, title = {Exact Pattern Matching for {RNA} Structure Ensembles}, booktitle = {Proceedings of the 16th International Conference on Research in Computational Molecular Biology (RECOMB 2012)}, pages = {245-260}, year = 2012, series = {LNCS}, volume = 7262, isbn = {978-3-642-29626-0}, editors = {Benny Chor}, publisher = {Springer-Verlag}, user = {will}, doi = {10.1007/978-3-642-29627-7_27}, abstract = {ExpaRNA's core algorithm computes, for two fixed RNA structures, a maximal non-overlapping set of maximal exact matchings. We introduce an algorithm ExpaRNA-P that solves the lifted problem of finding such sets of exact matchings in entire Boltzmann-distributed structure ensembles of two RNAs. Due to a novel kind of structural sparsification, the new algorithm maintains the time and space complexity of the algorithm for fixed input structures. Furthermore, we generalized the chaining algorithm of ExpaRNA in order to compute a compatible subset of ExpaRNA-P's exact matchings.We show that ExpaRNA-P outperforms ExpaRNA in BRAliBase 2.1 benchmarks, where we pass the chained exact matchings as anchor constraints to the RNA alignment tool LocARNA. Compared to LocARNA, this novel approach shows similar accuracy but is six times faster.} }