@Article{Rehfeld_Maticzka_Grosser-The_RNA_prote-2018,
  author =	 {Rehfeld, Frederick and Maticzka, Daniel and Grosser, Sabine 
                  and Knauff, Pina and Eravci, Murat and Vida, Imre and 
                  Backofen, Rolf and Wulczyn, F. Gregory},
  title =	 {The {RNA}-binding protein {ARPP21} controls dendritic 
                  branching by functionally opposing the {miRNA} it hosts},
  journal =	 {Nat Commun},
  year =	 {2018},
  volume =	 {9},
  number =	 {1},
  pages =	 {1235},
  user =	 {maticzkd},
  pmid =	 {29581509},
  doi = 	 {10.1038/s41467-018-03681-3},
  issn = 	 {2041-1723},
  abstract =	 {About half of mammalian miRNA genes lie within introns of 
                  protein-coding genes, yet little is known about functional 
                  interactions between miRNAs and their host genes. The 
                  intronic miRNA miR-128 regulates neuronal excitability and 
                  dendritic morphology of principal neurons during mouse 
                  cerebral cortex development. Its conserved host genes, 
                  R3hdm1 and Arpp21, are predicted RNA-binding proteins. Here 
                  we use iCLIP to characterize ARPP21 recognition of 
                  uridine-rich sequences with high specificity for 3'UTRs. 
                  ARPP21 antagonizes miR-128 activity by co-regulating a 
                  subset of miR-128 target mRNAs enriched for 
                  neurodevelopmental functions. Protein-protein interaction 
                  data and functional assays suggest that ARPP21 acts as a 
                  positive post-transcriptional regulator by interacting with 
                  the translation initiation complex eIF4F. This molecular 
                  antagonism is reflected in inverse activities during 
                  dendritogenesis: miR-128 overexpression or knockdown of 
                  ARPP21 reduces dendritic complexity; ectopic ARPP21 leads to 
                  an increase. Thus, we describe a unique example of 
                  convergent function by two products of a single gene.}
}