@Article{Prasse_Ehlers_Backofen-Regul_RNAs_archa-2013,
  author =	 {Prasse, Daniela and Ehlers, Claudia and Backofen, Rolf and 
                  Schmitz, Ruth A.},
  title =	 {Regulatory {RNAs} in archaea: first target identification 
                  in {Methanoarchaea}},
  journal =	 {Biochem Soc Trans},
  year =	 {2013},
  volume =	 {41},
  number =	 {1},
  pages =	 {344-9},
  user =	 {arichter},
  pmid =	 {23356309},
  doi = 	 {10.1042/BST20120280},
  issn = 	 {1470-8752},
  issn = 	 {0300-5127},
  abstract =	 {sRNAs (small non-coding RNAs) representing important 
                  players in many cellular and regulatory processes have been 
                  identified in all three domains of life. In Eukarya and 
                  Bacteria, functions have been assigned for many sRNAs, 
                  whereas the sRNA populations in Archaea are considerably 
                  less well characterized. Recent analyses on a genome-wide 
                  scale particularly using high-throughput sequencing 
                  techniques demonstrated the presence of high numbers of sRNA 
                  candidates in several archaea. However, elucidation of the 
                  molecular mechanism of sRNA action, as well as understanding 
                  their physiological roles, is in general still challenging, 
                  particularly in Archaea, since efficient genetic tools are 
                  missing. The identification of cellular targets of 
                  identified archaeal sRNAs by experimental approaches or 
                  computational prediction programs has begun only recently. 
                  At present, targets have been identified for one archaeal 
                  sRNA, sRNA162 in Methanosarcina mazei, which interacts with 
                  the 5' region of its targets, a cis-encoded and a 
                  trans-encoded target, blurring the paradigm of a border 
                  between cis- and trans-encoded sRNAs. Besides, the first 
                  experimental implications have been obtained in Haloarchaea 
                  and Pyrobaculum that archaeal sRNAs also target 3' regions 
                  of mRNAs. The present review summarizes our current 
                  knowledge on archaeal sRNAs and their biological functions 
                  and targets.}
}