@InProceedings{Moehl:Will:Backofen:CPM2008, author = {Mathias M{\"o}hl and Sebastian Will and Rolf Backofen}, title = {Fixed Parameter Tractable Alignment of {RNA} Structures Including Arbitrary Pseudoknots}, booktitle = {Proceedings of the 19th Annual Symposium on Combinatorial Pattern Matching (CPM 2008)}, year = 2008, pages = {69-81}, series = {LNCS}, vol = 5029, publisher = {Springer-Verlag}, abstract = {We present an algorithm that computes the edit distance of two RNA structures with arbitrary kinds of pseudoknots. A main benefit of the algorithm is that, despite the problem is NP-hard, the algorithmic complexity adapts to the complexity of the RNA structures. Due to fixed parameter tractability, we can guarantee polynomial run-time for a parameter which is small in practice. Our algorithm can be considered as a generalization of the algorithm of Jiang et al.~(Jiang, 2002) to arbitrary pseudoknots. In their absence, it gracefully degrades to the same polynomial algorithm. A prototypical implementation demonstrates the applicability of the method.}, user = {will} }