@Article{Maccari_Fuchs_Kury-disti_popul_and-2021,
  author =	 {Maccari, Maria Elena and Fuchs, Sebastian and Kury, Patrick 
                  and Andrieux, Geoffroy and Volkl, Simon and Bengsch, Bertram 
                  and Lorenz, Myriam Ricarda and Heeg, Maximilian and Rohr, 
                  Jan and Jagle, Sabine and Castro, Carla N. and Gross, Miriam 
                  and Warthorst, Ursula and Konig, Christoph and Fuchs, Ilka 
                  and Speckmann, Carsten and Thalhammer, Julian and Kapp, 
                  Friedrich G. and Seidel, Markus G. and Duckers, Gregor and 
                  Schonberger, Stefan and Schutz, Catharina and Fuhrer, Marita 
                  and Kobbe, Robin and Holzinger, Dirk and Klemann, Christian 
                  and Smisek, Petr and Owens, Stephen and Horneff, Gerd and 
                  Kolb, Reinhard and Naumann-Bartsch, Nora and Miano, Maurizio 
                  and Staniek, Julian and Rizzi, Marta and Kalina, Tomas and 
                  Schneider, Pascal and Erxleben, Anika and Backofen, Rolf and 
                  Ekici, Arif and Niemeyer, Charlotte M. and Warnatz, Klaus 
                  and Grimbacher, Bodo and Eibel, Hermann and Mackensen, 
                  Andreas and Frei, Andreas Philipp and Schwarz, Klaus and 
                  Boerries, Melanie and Ehl, Stephan and Rensing-Ehl, Anne},
  title =	 {A distinct {CD38}+{CD45RA}+ population of {CD4}+, {CD8}+, 
                  and double-negative {T} cells is controlled by {FAS}},
  journal =	 {J Exp Med},
  year =	 {2021},
  volume =	 {218},
  number =	 {2},
  pages =	 {},
  user =	 {backofen},
  pmid =	 {33170215},
  doi = 	 {10.1084/jem.20192191},
  issn = 	 {0022-1007},
  issn = 	 {1540-9538},
  abstract =	 {The identification and characterization of rare immune cell 
                  populations in humans can be facilitated by their growth 
                  advantage in the context of specific genetic diseases. Here, 
                  we use autoimmune lymphoproliferative syndrome to identify a 
                  population of FAS-controlled TCRalphabeta+ T cells. They 
                  include CD4+, CD8+, and double-negative T cells and can be 
                  defined by a CD38+CD45RA+T-BET- expression pattern. These 
                  unconventional T cells are present in healthy individuals, 
                  are generated before birth, are enriched in lymphoid tissue, 
                  and do not expand during acute viral infection. They are 
                  characterized by a unique molecular signature that is 
                  unambiguously different from other known T cell 
                  differentiation subsets and independent of CD4 or CD8 
                  expression. Functionally, FAS-controlled T cells represent 
                  highly proliferative, noncytotoxic T cells with an IL-10 
                  cytokine bias. Mechanistically, regulation of this 
                  physiological population is mediated by FAS and CTLA4 
                  signaling, and its survival is enhanced by mTOR and STAT3 
                  signals. Genetic alterations in these pathways result in 
                  expansion of FAS-controlled T cells, which can cause 
                  significant lymphoproliferative disease.}
}