@Article{Holzer_Krahling_Amman-Diffe_trans_respo-2016,
  author =	 {Holzer, Martin and Krahling, Verena and Amman, Fabian and 
                  Barth, Emanuel and Bernhart, Stephan H. and Carmelo, Victor 
                  A. O. and Collatz, Maximilian and Doose, Gero and 
                  Eggenhofer, Florian and Ewald, Jan and Fallmann, Jorg and 
                  Feldhahn, Lasse M. and Fricke, Markus and Gebauer, Juliane 
                  and Gruber, Andreas J. and Hufsky, Franziska and Indrischek, 
                  Henrike and Kanton, Sabina and Linde, Jorg and Mostajo, 
                  Nelly and Ochsenreiter, Roman and Riege, Konstantin and 
                  Rivarola-Duarte, Lorena and Sahyoun, Abdullah H. and 
                  Saunders, Sita J. and Seemann, Stefan E. and Tanzer, Andrea 
                  and Vogel, Bertram and Wehner, Stefanie and Wolfinger, 
                  Michael T. and Backofen, Rolf and Gorodkin, Jan and Grosse, 
                  Ivo and Hofacker, Ivo and Hoffmann, Steve and Kaleta, 
                  Christoph and Stadler, Peter F. and Becker, Stephan and 
                  Marz, Manja},
  title =	 {Differential transcriptional responses to {Ebola} and 
                  {Marburg} virus infection in bat and human cells},
  journal =	 {Sci Rep},
  year =	 {2016},
  volume =	 {6},
  number =	 {},
  pages =	 {34589},
  user =	 {sita},
  pmid =	 {27713552},
  doi = 	 {10.1038/srep34589},
  issn = 	 {2045-2322},
  abstract =	 {The unprecedented outbreak of Ebola in West Africa resulted 
                  in over 28,000 cases and 11,000 deaths, underlining the need 
                  for a better understanding of the biology of this highly 
                  pathogenic virus to develop specific counter strategies. Two 
                  filoviruses, the Ebola and Marburg viruses, result in a 
                  severe and often fatal infection in humans. However, bats 
                  are natural hosts and survive filovirus infections without 
                  obvious symptoms. The molecular basis of this striking 
                  difference in the response to filovirus infections is not 
                  well understood. We report a systematic overview of 
                  differentially expressed genes, activity motifs and pathways 
                  in human and bat cells infected with the Ebola and Marburg 
                  viruses, and we demonstrate that the replication of 
                  filoviruses is more rapid in human cells than in bat cells. 
                  We also found that the most strongly regulated genes upon 
                  filovirus infection are chemokine ligands and transcription 
                  factors. We observed a strong induction of the JAK/STAT 
                  pathway, of several genes encoding inhibitors of MAP kinases 
                  (DUSP genes) and of PPP1R15A, which is involved in ER 
                  stress-induced cell death. We used comparative 
                  transcriptomics to provide a data resource that can be used 
                  to identify cellular responses that might allow bats to 
                  survive filovirus infections.}
}