@Article{Grzejda_Mach_Schweizer-The_long_nonco-2022,
  author =	 {Grzejda, Dominika and Mach, Jana and Schweizer, Johanna 
                  Aurelia and Hummel, Barbara and Rezansoff, Andrew Mischa and 
                  Eggenhofer, Florian and Panhale, Amol and Lalioti, 
                  Maria-Eleni and Cabezas Wallscheid, Nina and Backofen, Rolf 
                  and Felsenberg, Johannes and Hilgers, Valerie},
  title =	 {The long noncoding {RNA} mimi scaffolds neuronal granules 
                  to maintain nervous system maturity},
  journal =	 {Sci Adv},
  year =	 {2022},
  volume =	 {8},
  number =	 {39},
  pages =	 {eabo5578},
  user =	 {backofen},
  pmid =	 {36170367},
  doi = 	 {10.1126/sciadv.abo5578},
  issn = 	 {2375-2548},
  abstract =	 {RNA binding proteins and messenger RNAs (mRNAs) assemble 
                  into ribonucleoprotein granules that regulate mRNA 
                  trafficking, local translation, and turnover. The 
                  dysregulation of RNA-protein condensation disturbs synaptic 
                  plasticity and neuron survival and has been widely 
                  associated with human neurological disease. Neuronal 
                  granules are thought to condense around particular proteins 
                  that dictate the identity and composition of each granule 
                  type. Here, we show in Drosophila that a previously 
                  uncharacterized long noncoding RNA, mimi, is required to 
                  scaffold large neuronal granules in the adult nervous 
                  system. Neuronal ELAV-like proteins directly bind mimi and 
                  mediate granule assembly, while Staufen maintains condensate 
                  integrity. mimi granules contain mRNAs and proteins involved 
                  in synaptic processes; granule loss in mimi mutant flies 
                  impairs nervous system maturity and neuropeptide-mediated 
                  signaling and causes phenotypes of neurodegeneration. Our 
                  work reports an architectural RNA for a neuronal granule and 
                  provides a handle to interrogate functions of a condensate 
                  independently of those of its constituent proteins.}
}