@ARTICLE{Gruning_Yusuf-SARS_CoV_2_submission_ENA_Bioinformatics2021, title = "A {SARS-CoV-2} sequence submission tool for the European Nucleotide Archive", author = "Roncoroni, Miguel and Droesbeke, Bert and Eguinoa, Ignacio and De Ruyck, Kim and D'Anna, Flora and Yusuf, Dilmurat and Gr{\"u}ning, Bj{\"o}rn and Backofen, Rolf and Coppens, Frederik", abstract = "SUMMARY: Many aspects of the global response to the COVID-19 pandemic are enabled by the fast and open publication of SARS-CoV-2 genetic sequence data. The European Nucleotide Archive (ENA) is the European recommended open repository for genetic sequences. In this work, we present a tool for submitting raw sequencing reads of SARS-CoV-2 to ENA. The tool features a single-step submission process, a graphical user interface, tabular-formatted metadata and the possibility to remove human reads prior to submission. A Galaxy wrap of the tool allows users with little or no bioinformatic knowledge to do bulk sequencing read submissions. The tool is also packed in a Docker container to ease deployment. AVAILABILITY: CLI ENA upload tool is available at github.com/usegalaxy-eu/ena-upload-cli (DOI 10.5281/zenodo.4537621); Galaxy ENA upload tool at toolshed.g2.bx.psu.edu/view/iuc/ena\_upload/382518f24d6d and https://github.com/galaxyproject/tools-iuc/tree/master/tools/ena\_upload (development) and; ENA upload Galaxy container at github.com/ELIXIR-Belgium/ena-upload-container (DOI 10.5281/zenodo.4730785).", journal = "Bioinformatics", month = jun, year = 2021, language = "en", doi = "10.1093/bioinformatics/btab421", issn = "1367-4803", user = {cuyghur} }