@Article{Del_Vecchio_De_Vito_Saunders-RNA_prote_HuR-2016,
  author =	 {Del Vecchio, Giorgia and De Vito, Francesca and Saunders, 
                  Sita J. and Risi, Adele and Mannironi, Cecilia and Bozzoni, 
                  Irene and Presutti, Carlo},
  title =	 {{RNA}-binding protein {HuR} and the members of the 
                  {miR}-200 family play an unconventional role in the 
                  regulation of c-{Jun} {mRNA}},
  journal =	 {RNA},
  year =	 {2016},
  volume =	 {22},
  number =	 {10},
  pages =	 {1510-21},
  user =	 {sita},
  pmid =	 {27473170},
  doi = 	 {10.1261/rna.057588.116},
  issn = 	 {1355-8382},
  issn = 	 {1469-9001},
  abstract =	 {Post-transcriptional gene regulation is a fundamental step 
                  for coordinating cellular response in a variety of 
                  processes. RNA-binding proteins (RBPs) and microRNAs 
                  (miRNAs) are the most important factors responsible for this 
                  regulation. Here we report that different components of the 
                  miR-200 family are involved in c-Jun mRNA regulation with 
                  the opposite effect. While miR-200b inhibits c-Jun protein 
                  production, miR-200a tends to increase the JUN amount 
                  through a stabilization of its mRNA. This action is 
                  dependent on the presence of the RBP HuR that binds the 
                  3'UTR of c-Jun mRNA in a region including the mir-200a 
                  binding site. The position of the binding site is 
                  fundamental; by mutating this site, we demonstrate that the 
                  effect is not micro-RNA specific. These results indicate 
                  that miR-200a triggers a microRNA-mediated stabilization of 
                  c-Jun mRNA, promoting the binding of HuR with c-Jun mRNA. 
                  This is the first example of a positive regulation exerted 
                  by a microRNA on an important oncogene in proliferating 
                  cells.}
}