@Article{Backofen_Vogel-Biolo_and_bioin-2014,
  author =	 {Backofen, Rolf and Vogel, Tanja},
  title =	 {Biological and bioinformatical approaches to study 
                  crosstalk of long-non-coding {RNAs} and chromatin-modifying 
                  proteins},
  journal =	 {Cell Tissue Res},
  year =	 {2014},
  volume =	 {356},
  number =	 {3},
  pages =	 {507-26},
  user =	 {maticzkd},
  pmid =	 {24820400},
  doi = 	 {10.1007/s00441-014-1885-x},
  issn = 	 {1432-0878},
  issn = 	 {0302-766X},
  abstract =	 {Long-non-coding RNA (lncRNA) regulates gene expression 
                  through transcriptional and epigenetic regulation as well as 
                  alternative splicing in the nucleus. In addition, regulation 
                  is achieved at the levels of mRNA translation, storage and 
                  degradation in the cytoplasm. During recent years, several 
                  studies have described the interaction of lncRNAs with 
                  enzymes that confer so-called epigenetic modifications, such 
                  as DNA methylation, histone modifications and chromatin 
                  structure or remodelling. LncRNA interaction with 
                  chromatin-modifying enzymes (CME) is an emerging field that 
                  confers another layer of complexity in transcriptional 
                  regulation. Given that CME-lncRNA interactions have been 
                  identified in many biological processes, ranging from 
                  development to disease, comprehensive understanding of 
                  underlying mechanisms is important to inspire basic and 
                  translational research in the future. In this review, we 
                  highlight recent findings to extend our understanding about 
                  the functional interdependencies between lncRNAs and CMEs 
                  that activate or repress gene expression. We focus on recent 
                  highlights of molecular and functional roles for CME-lncRNAs 
                  and provide an interdisciplinary overview of recent 
                  technical and methodological developments that have improved 
                  biological and bioinformatical approaches for detection and 
                  functional studies of CME-lncRNA interaction.}
}