@Article{Backofen_Gorodkin_Hofacker-Compa_RNA_Genom-2018,
  author =	 {Backofen, Rolf and Gorodkin, Jan and Hofacker, Ivo L. and 
                  Stadler, Peter F.},
  title =	 {Comparative {RNA} {Genomics}},
  journal =	 {Methods Mol Biol},
  year =	 {2018},
  volume =	 {1704},
  number =	 {},
  pages =	 {363-400},
  user =	 {backofen},
  pmid =	 {29277874},
  doi = 	 {10.1007/978-1-4939-7463-4_14},
  issn = 	 {1940-6029},
  issn = 	 {1064-3745},
  abstract =	 {Over the last two decades it has become clear that RNA is 
                  much more than just a boring intermediate in protein 
                  expression. Ancient RNAs still appear in the core 
                  information metabolism and comprise a surprisingly large 
                  component in bacterial gene regulation. A common theme with 
                  these types of mostly small RNAs is their reliance of 
                  conserved secondary structures. Large scale sequencing 
                  projects, on the other hand, have profoundly changed our 
                  understanding of eukaryotic genomes. Pervasively 
                  transcribed, they give rise to a plethora of large and 
                  evolutionarily extremely flexible noncoding RNAs that exert 
                  a vastly diverse array of molecule functions. In this 
                  chapter we provide a-necessarily incomplete-overview of the 
                  current state of comparative analysis of noncoding RNAs, 
                  emphasizing computational approaches as a means to gain a 
                  global picture of the modern RNA world.}
}